Opposing Effects of IL-1Ra and IL-36Ra on Innate Immune Response to Pseudomonas aeruginosa Infection in C57BL/6 Mouse Corneas

Innate immune responses of human tracheal epithelium to Pseudomonas aeruginosa flagellin, TNF- , and IL-1

Tseng, Jill, Jiun Do, Jonathan H. Widdicombe, and Terry E. Machen. Innate immune responses of human tracheal epithelium to Pseudomonas aeruginosa flagellin, TNF, and IL-1 . Am J Physiol Cell Physiol 290: C678–C690, 2006. First published October 26, 2005; doi:10.1152/ajpcell.00166.2005.—We measured innate immune responses by primary human tracheal epithelial (HTE) cells grown as confluent, pseud...

Nod1 participates in the innate immune response to Pseudomonas aeruginosa.

The mammalian innate immune system recognizes pathogen-associated molecular patterns through pathogen recognition receptors. Nod1 has been described recently as a cytosolic receptor that detects specifically diaminopimelate-containing muropeptides from Gram-negative bacteria peptidoglycan. In the present study we investigated the potential role of Nod1 in the innate immune response against the ...

IL-1B-31 and IL-1Ra polymorphisms associated with increased host susceptibility to immune thrompocytopenia

IL-15 Participates in the Respiratory Innate Immune Response to Influenza Virus Infection

Following influenza infection, natural killer (NK) cells function as interim effectors by suppressing viral replication until CD8 T cells are activated, proliferate, and are mobilized within the respiratory tract. Thus, NK cells are an important first line of defense against influenza virus. Here, in a murine model of influenza, we show that virally-induced IL-15 facilitates the trafficking of ...

Competition of IL-1 and IL-1ra determines lymphocyte response to delayed stimulation with PHA.

BACKGROUND Human peripheral blood mononuclear cells (PBMC) left in microcultures for 24h without mitogen do not respond to subsequent stimulation with PHA. They regain reactivity if the native culture medium is absorbed with other party lymphocytes or partially replaced with the medium from a PHA-stimulated culture. The observations suggest that, during the incubation, some inhibitory agent had...